https://touchingfish.top/en/tags/splice-site/Recent content in Splice-Site on TouchingFish.topHugoenSun, 21 Feb 2021 00:00:00 +0000https://touchingfish.top/en/2021/alternative-splice-algorithm/Sun, 21 Feb 2021 00:00:00 +0000https://touchingfish.top/en/2021/alternative-splice-algorithm/<h2 id="1-biological-background">1. Biological Background</h2> <h3 id="11-what-is-alternative-splicing">1.1 What is Alternative Splicing</h3> <p>In eukaryotes, a single gene can produce multiple mRNA isoforms through alternative splicing (AS) -- the process by which different combinations of exons are joined during pre-mRNA splicing. This greatly expands proteomic diversity without increasing gene count.</p> <p>A gene with N exons can theoretically produce up to 2^(N-1) splice variants. In practice, most genes produce 2-10 isoforms, but some (e.g., Drosophila Dscam) can produce tens of thousands.</p>